Muscle health undergoes a natural decline after the third decade of life. Skeletal muscle mass decreases alongside a loss in strength. Urolithin A improves mitochondrial and muscle function, providing more energy to cells. It is a naturally-occurring anti-aging compound that can benefit anyone looking to proactively maintain muscle health.
In laboratory studies, Urolithin A was shown to induce a selective recycling of mitochondria, a process known as mitophagy. This is a natural process inside of our cells to clean up defective and unhealthy mitochondria. Mitophagy becomes less efficient as we age (Ryu et al, 2016). Urolithin A has been shown to stimulate mitophagy in a conserved manner across different species, including C. elegans, rodents, and in human cells (Ryu et al, 2016).
Urolithin A is generated by the gut microflora as a natural food metabolite of ellagitannins, a class of compounds found in the pomegranate and other fruits and nuts. Sources of ellagitannins include: pomegranates, nuts, some berries (raspberries, strawberries, blackberries, cloudberries), tea, muscadine grapes, tropical fruits, and oak-aged wines. However, consuming these foods does not guarantee the transformation of ellagitannins into Urolithin A. See the next question.
Conversion rates vary from person to person. Upon consumption of pomegranate juice, for example, compounds known as ellagitannins are broken down in the stomach and transformed by intestinal bacteria into Urolithin A. This biotransformation has been shown to vary widely across individuals, with some showing high or low conversion rates, while others are unable to perform the conversion at all. (García-Villalba R et al, 2017).
The health benefits of Urolithin A were brought to life by the innovative life science company Amazentis in collaboration with leading scientists in Switzerland. Amazentis employs today’s leading research and clinical science to discover and develop the next generation of advanced nutrition. The Company’s lead product candidate, Urolithin A, is the result of over 10 years of research. For more information, please visit www.amazentis.com. This site is intended to be a resource for anyone interested in the science of cellular and muscle health, as well as the anti-aging properties of Urolithin A.
Amazentis has established a technology portfolio and proprietary knowhow around Urolithin A, enabling the manufacture and development of advanced nutrition products. Consumer health products containing Urolithin A are under development and a commercial launch is planned. Please sign up for updates if you would like us to keep you informed and to notify you when these products become available.